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247 In addition, p53 protein levels are elevated in senescent cells and exacerbate centromere inactivation through the negative regulation of CENP-A expression

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Furthermore, studies of IGF-2 gene in transitional cell carcinoma of the bladder and MGMT gene in gastric cancer showed that patients with CT or TT MTHFR genotypes had reduced methylation of IGF-2 or MGMT compared those with CC genotype 36,37