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The similar viewpoints were also supported by other critical reviews and clinical trials (58), and inferred that GLP-1RA could be considered in patients at a high risk of, or with established cardiovascular diseases to improve the prognosis of cardiovascular events (especially nonfatal stroke), whilst SGLT2i could be recommended for patients with heart failure or chronic kidney diseases

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However, when fatty acid delivery exceeds mitochondrial oxidative and redox-buffering capacity, increased electron transport pressure can elevate reactive oxygen species (ROS) production, promote endoplasmic reticulum stress, and increase susceptibility to lipid peroxidation [54, 61,62,63]