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Glutathione supplementation in its reduced form (GSH, 500 mg/d) has been shown to lighten skin

Gastrointestinal Effects The most commonly reported adverse effects are gastrointestinal in nature, including: Nausea and vomiting (affecting 20-40% of patients initially, varying by agent and dose) [8] Diarrhoea or constipation Abdominal discomfort and bloating Reduced appetite In elderly patients, persistent nausea and vomiting can lead to dehydration and electrolyte imbalances more rapidly than in younger adults

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Patient-specific prescriptions in narrow circumstances remain a fact-specific legal question that depends on state board interpretation, the pharmacists judgment, and the prescribers clinical rationale not a green light from the FDA

Metformin as a potential antidepressant: Mechanisms and therapeutic insights in depression