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Strategies such as amino acid substitution or cyclization, PEGylation, fusion of long-acting fragments (fusion with Fc, fusion with human serum albumin), and conjugation of fatty acid chains are commonly used, and several drugs have been successfully marketed

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Ketamine is currently the best-studied hallucinogen in the field of sustained antidepressant effect [17,18,19,20], and with psilocybin being granted breakthrough therapy for the treatment of depression by the U.S