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It typically appears within 24 to 72 hours of an injection and diminishes over the following days

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An RCT including 85 women with different indications for ICSI who have been supplemented with AOX daily from the cycle preceding ICSI cycle, versus 85 women who were not given any AOX acting as controls, concluded that AOX therapy did not change clinical or laboratory outcomes (225)

Clinical improvement of moderate depression with a combination of rhodiola and saffron in a non-student population: a double-blind, placebo-controlled study