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[12] [13] In August 2008, four additional deaths from pancreatitis in users of exenatide were reported to the FDA

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Ustekinumab, a fully human IgG1 antibody targeting the shared p40 subunit of both IL-23 and IL-12, achieved 15.6% week 8 remission (6 mg/kg IV induction) versus 5.3% placebo and 43.8% week 44 remission (90mg SC every 812 weeks) versus 24.0% placebo in UNIFI trials ( Next-generation anti-interleukin strategies employ innovative approaches: oral peptide IL-23 receptor antagonists with gut-selective blockade and picomolar affinity (icotrokinra), optimized IL-23p19 inhibitors (picankibart, brazikumab), selective gp130 trans-signaling inhibitors preserving classical IL-6 signaling (olamkicept), IL-4R antagonists for type 2-driven disease (dupilumab), IL-36 receptor antagonists (spesolimab), CD127/IL-7R antagonists (lusvertikimab), IL-1 neutralizing antibodies (lutikizumab), and IL-13-specific inhibitors (anrukinzumab, tralokinumab)

These medications mimic the GLP-1 hormone, which helps control insulin and blood sugar levels, decreases appetite and slows digestion of food

Sener, B