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Animal studies have shown that TMAO induces vascular inflammation by activating the sirtuin 3 -superoxide dismutase 2- mitochondrial ROS (SIRT3SOD2mtROS) and stimulating in vitro and in vivo formation of the NLRP3 inflammasome (Seldin et al., 2016)

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Preclinical pharmacokinetics, tissue distribution and in vitro metabolism of FHND6091, a novel oral proteasome inhibitor

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