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The Receptor Knockout Proof : To isolate the mechanical pathway, neuroscientists deployed genetically modified mice with their GLP-1 receptors entirely knocked out

These findings indicate that hyperglycemia induces Mller cell ferroptosis via iron overload, lipid peroxidation and Xc - GSHGPX4 axis dysfunction, which further exacerbates neuroinflammation through microglial reactivation and impairs the BRB

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S., Gomez, J

In addition, PFOS can induce autophagy activation with increased Beclin and LC3BII expression through reactive oxygen species (ROS)-mediated extracellular signalregulated kinase (ERK) activation, which is followed by impeded autophagic flux, increased lysosomal membrane permeability (LMP), and, consequently, RTC apoptosis