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doi: 10.1210/jc.2015-2335 69 PocaiACarringtonPEAdamsJRWrightMEiermannGZhuLet al

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Together, compensatory biceps-dominant activation and chronic supraspinatus unloading provide a mechanistic link between rotator cuff injury and sustained mitochondrial reactive oxygen species elevation, thereby facilitating activation of proteolytic and atrophy-related signaling pathways that drive progressive muscle degeneration