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CircHIPK3 is one of the most abundant circRNAs in -cells and regulates hyperglycemia and IR by sequestering miR-124-3p and miR-338-3p, thereby increasing mRNA expression of key -cell genes (e.g., Slc2a2 , Akt1 , and Mtpn ), insulin secretion, and -cell proliferation

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Clinical data and normalized read counts generated from RNA-sequencing were downloaded using cBioPortal [55, 56] and the TCGA2STAT R-package, respectively [57]