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in 2015 showed that rats exposed to hyperthermia for about 30 minutes experienced generalized seizures and impairments in learning and memory in the Morris water maze test [3]

The trick: finding the balance of hydration

And preclinical models consistently show benefits for Alzheimers-like pathology. In addition, a combination of their anti-inflammatory effects and effects on the vasculature likely explain some of the beneficial effects on dementia reported in observational studies, Holst says

It demonstrated to have a safety profile similar to GLP-1RA not increasing the risk of hypoglycemia (48)

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