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A 2024 review found that serious complications are uncommon, with mild and short-lived reactions being the most common

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Clinical trials demonstrated modest efficacy, with approximately one to two fewer hot flashes daily compared to placebo

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With their dual action on metabolic and skeletal pathways, DACRAs offer a unique combination of weight loss, pain relief, and a positive influence on joint structures, distinguishing them from other weight-loss pharmacotherapies and making them a worthy candidate for further investigation in osteoarthritis, particularly when driven by metabolic dysfunction