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Feeling down or off after starting a GLP-1 could be due to uncomfortable GI side effects or frustration if weight loss is slower than expected, says Pagoto

Weight loss outcomes are generally dose dependent

Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications originally developed for type 2 diabetes management

Considering these numbers, there is a huge opportunity to treat obesity and thereby significantly reduce further growth in the number of people developing Type 2 diabetes, as well as other life-threatening conditions

For intracellular staining, cells after surface staining were fixed in Fixation Buffer (Biolegend, #420801) at room temperature for 30 min