doi:10.1124/molpharm.121.000270 3
4.1 Clinical relevance of the CLP model The CLP model was selected for its unique ability to recapitulate core clinical features of SAE: polymicrobial sepsis, hippocampal neurodegeneration, and chronic cognitive impairment ( 4.2 Microglia-mediated oxidative neuronal injury Microglial activation initiates neuronal damage, and a previous study revealed that the microglial inhibitor minocycline reduces neuronal apoptosis ( in vivo oxidative stress ( Mechanistically, a microglial inflammation-oxidative stress feedforward loop perpetuates injury: Activated microglia secrete neurotoxins, impairing neuronal mitochondrial function and antioxidant capacity (such as GPX4), thus increasing ROS leakage
This drives the propensity to consume energy-dense UPFs during emotional eating, forming a bidirectional relationship between UPF intake and mental disorder (20, 47)
Private access through regulated online pharmacies is the most common route for patients who do not qualify for, or cannot wait for, NHS treatment
B vitamins and folic acid
