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142 Additionally, mucin 20 (MUC20), a member of the mucin family encoded by human genes, represses CDKN2A expression by suppressing IGF-1R lactylation, triggering MET inactivation and cuproptosis to hinder proteasome inhibitor resistance in multiple myeloma cells

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However, PGPIPN treatment could rectify these changes, including decreasing TG, TC and LDL-C levels and increasing HDL-C level (Figure 6A)