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Oral GLP-1: Efficacy and Tolerability in Practice Injectable semaglutide achieves peak plasma concentrations faster and maintains more stable levels than oral formulations, translating to more predictable hunger suppression and fewer gastrointestinal side effects at equivalent doses

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However, humans and monkeys express lower levels of the GLP-1 receptor in thyroid C-cells than rodents, and GLP-1 receptor agonists are unlikely to stimulate adenylate cyclase or increase calcitonin release in primates [65]

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