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Additional important safety considerations include: Risk of hypoglycaemia when combined with insulin or sulfonylureas Potential for dehydration and acute kidney injury from severe gastrointestinal symptoms Increased risk of diabetic retinopathy complications with rapid glucose lowering, particularly with semaglutide Importantly, memory loss or cognitive impairment is not listed among the recognised adverse effects in the Summary of Product Characteristics (SmPC) for any GLP-1 receptor agonist licensed in the UK

Consider UTI evaluation if urinary symptoms prominent, as GSM and infections can overlap

The medication has a half-life of about seven days , which means that a missed dose can disrupt your progress, particularly if youre in the early stages of treatment

Michel Choueiri, told NPR in an email after a broadcast version of this story aired

When injection site problems signal something bigger Most injection site issues are localized and temporary