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Nevertheless, important uncertainties remain, including the degree of brain penetrance across individual agents, the relative contributions of central versus peripheral mechanisms, biomarkers of target engagement, and the patient subgroups most likely to benefit

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We did not detect any dierences in the behaviour of the drug-injected mice compared to the controls (Fig.5ac), although there was a trend for shorter open eld centre time in mice that received 0.7 mg/kg dose of bradyzide compared to vehicle controls (p = 0.075, Fig.5a)