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Furthermore, lixisenatide can cross the BBB at very low doses with obvious physiological activity, and promote neurogenesis in the CNS ( Along with T2DM-induced hyperglycemia, cerebral blood flow (CBF) is obviously decreased on account of regulation of vasculature and vasoactive mediators, especially endothelium-derived nitric oxide (NO) (161)

J Exp Med 197(10):13231334