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It also serves as an essential cofactor for non-redox NAD+-dependent enzymes, including sirtuins, CD38, and poly(ADP-ribose) polymerases (PARPs)

The cognitive sub-score moved 0.70 points the wrong way to matter and missed on its own

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This process may represent a compensatory, self-limiting response to oxidative overload, as KYNA reduces oxidative bursts in immune cells and promotes T-cell proliferation [170]