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In vitro studies using adipocyte cell lines, including 3T3-L1 cells and primary adipocyte cultures, have used this compound to examine lipolytic signalling, triglyceride hydrolysis mechanisms, fatty acid oxidation pathways, and adipokine secretion
In vivo and in vitro experiments have shown that the Dox-exosomes process possesses high efficacy in Dox delivery and targeting to breast cancer, effective cancer suppression, and low toxicity (Tian et al., 2014)
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Thus, TZDs regulate adipogenesis and fatty acid oxidation and promote adipose tissue ability to store lipids, decreasing circulating fatty acids and improving insulin resistance, whereas they decrease lipotoxicity and increase insulin sensitivity and glucose uptake in muscle ( Cardiovascular Outcomes Several randomized trials showed a potential for cardiovascular benefit with TDZs (Table 1)
