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Tirzepatide (a dual GLP-1/GIP agonist) produced even larger reductionsup to 22% body weight loss in SURPASS trialsmaking it an option for patients with higher weight loss targets

Therefore, considering the potential association between cholecystectomy and PBH, it may be prudent to initiate treatment with acarbose at higher doses in patients with a history of cholecystectomy

The baseline HbA1c in the tirzepatide arms was 8.23%8.36% and 8.37% in the placebo group

The 16:8 protocol shows the highest compliance rates among intermittent fasting methods