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For topical skincare, timing is a minor optimization, twice-daily use is a sensible default, but consistency over weeks matters far more than hitting an exact hour

2 3 4 5 Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women PubMed An open-label, single-arm trial of the safety and efficacy of a novel preparation of glutathione as a skin-lightening agent in Filipino women PubMed Systemic Glutathione as a Skin-Whitening Agent in Adult PubMed Intravenous Nutrient Therapy: The Myers Cocktail PubMedNational Library of Medicine PubMed Glutathione and its antiaging and antimelanogenic effects PMC FDA warns compounders not to use glutathione from Letco Medical to compound sterile drugs | FDA FDA reminds compounders to use ingredients suitable for sterile compounding | FDA

However, note that using higher concentrations of a product may not always be beneficial

Overview & Purpose in Skincare Kojic Acid is a naturally derived ingredient obtained from certain fungi and fermented foods like rice wine