In neurons, Grx has a protective effect on redox-sensitive enzymes and ion channels, meaning that its dysfunction is implicated in several neurodegenerative disorders involving protein misfolding and redox signaling dysregulation (Ogata et al., 2021)
In addition, GLP-1 expression was down-regulated in wild-type Lox5 cells knocked out by FNDC5, and the induced expressions of lipolysis and autophagy-related genes and proteins were also inhibited, such as ATGL, HSL, and hepatic lipase deficiency gene (LIPC), suggesting that GLP-1 expression is also regulated by FNDC5, and may also provide therapeutic targets for lipid metabolism-related diseases
Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder
PubMed: 16502757 AOD 9604 and Articular Cartilage Repair: Assessment in a Rat Cartilage Defect Model animal Black A, Huang AH, Yin Z, et al
Nature 616(7956):339347 Leone RD, Zhao L, Englert JM, Sun IM, Oh MH, Sun IH, Arwood ML, Bettencourt IA, Patel CH, Wen J, Tam A, Blosser RL, Prchalova E, Alt J, Rais R, Slusher BS, Powell JD (2019) Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion
