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As described above, the l-EV fraction co-expressing Halo7-Rac1 and FLAG-MIM I-BAR was prepared and labeled with a Halo ligand SF650B

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The combined rationale assumes these mechanisms may work synergistically

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Myo-inositol and selenium: a physiological rationale for thyroid function Myo-inositol and TSH signaling Myo-inositol acts as a TSH second messenger : within thyroid follicular cells, it is part of the phosphatidylinositol signalling pathway activated when TSH binds to its receptor