Central administration of GLP-1RAs reduces food intake, likely via GLP-1 receptorexpressing regions in the hypothalamus and brainstem (Kastin and Akerstrom, 2003), many of which are also estrogen targets (Kanoski et al., 2011), supporting a potential interaction between these systems (Miller, 2012)
Investor Presentations (Full Decks) 2006 R&D Day Presentation (PDF) - Phybrids platform, GIP mimetic program (slides 43, 46, 58-59) 2007 R&D Day Presentation (PDF) - Market sizing, obesity portfolio positioning (slides 14, 28, 29, 78) 2007 J.P
Oral formulations overcome barriers associated with injectable drugs, offering greater convenience and acceptance among patients who are reluctant or unable to use injections
Both T2DM and PD share insulin resistance as a contributing factor in disease progression
David Irwin, University of Toronto, Canada Updates Copyright 2021 Lindquist, Madsen, Bruner-Osborne, Rosenkilde and Hauser