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doi: 10.1371/journal.pone.0202662 104 Alavian-GhavaniniARueggJ

In the United States (US), it has been estimated that more than one in three adults and more than one in five children have prediabetes [15,17]

A high-affinity, saturable transport mechanism for DSIP at the blood-brain barrier was demonstrated in vascularly perfused guinea pig brain, with the highest unidirectional transfer rate in the hippocampus (Kin 1.66 L/min/g) [9]

A large comparative-effectiveness study published in JAMA Internal Medicine analyzed approximately 36,000 patients on SGLT2 inhibitors versus 19,000 on GLP-1 receptor agonists in Denmark (Jensen et al., 2026)

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