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11 A separate controlled trial comparing caloric restriction alone, exercise alone, and the combination found that the diet-only group lost about 16% of their weight as lean mass

555 A recent study in the elderly reported an age-dependent reduction in plasma ghrelin and an elevated ratio of plasma liver-expressed antimicrobial peptide 2 (LEAP2)/ghrelin, which is associated with cognitive impairment

82.4% achieved at least 10% weight loss