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Central to this shift is the recognition that intestinal reparative therapy, defined by objective endpoints such as endoscopic and histologic healing, is strongly associated with improved long-term outcomes

Limitations include limited demographic diversity (predominantly White and male participants) and the non-causal, post-randomization nature of analyses linking adiposity change to outcomes, which precludes definitive mechanistic inference and may limit generalisability to more diverse populations

Tape measurement standards vary by branch

The only definitive test is HPLC analysis showing intact peptide structure at 4,800 Da molecular weight with no fragment peaks