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This approach often reduces the frequency and severity of systemic side effects

Tan WC, Lo C, Jong A, Xing L, Fitzgerald MJ, Vollmer WM, Buist SA, Sin DD

The Look AHEAD: Action for Health in Diabetes (Look AHEAD) trial on the longer-term effects of an intensive lifestyle intervention in adults who were overweight/obese with type 2 diabetes showed improvements in diabetes control and complications, depression, physical function and health-related quality of life, sleep apnoea, incontinence, brain structure and healthcare use and costs, with positive impacts on composite indices of multimorbidity, geriatric syndromes and disability-free life-years

51 Notwithstanding, these agents are now favoured as first-line therapy, and might be particularly advantageous in patients with comorbid insomnia, peripheral neuropathy or anxiety

Yang, F., Luo, X., Li, J., Lei, Y., Zeng, F., Huang, X., Lan, Y., & Liu, R