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Moreover, the duration of impact on gastrin secretion after stopping medication is markedly different due to differences in pharmacokinetic profiles

CANADA CA2601784, the compound patent for semaglutide in Canada, was scheduled to expire in March 2026, however, due to Novo Nordisks failure to pay the required maintenance fees, the patent has lapsed and Novo Nordisk's market exclusivity for semaglutide in Canada officially ended on January 4, 2026

Missing data for key variables were handled using available case analysis, which included only the participants with complete data for those variables in the analysis

A portion of users report appetite changes, while just as many say they saw no noticeable difference

It is effective at promoting weight loss, although some patients may lose muscle along with fat and experience side effects like nausea due to its action on gut mechanoreceptors