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Last Updated: October 26, 2025 QUICK ANSWER: The 3 most common side effects are: Nausea, diarrhea and constipation

Extended pharmacokinetic studies were performed for RF-409 by injecting 125 I-RF-409 and collecting samples over a time course of 5225 minutes

The results are tabulated in Supplemental Information: Table S4, and the Area under the curve (AUC) is presented in Supplemental Information, figure S1A-C

Weight loss outcomes were as follows: In SURPASS-1, Mounjaro lowered weight by an average of 14 pounds (5 mg), 15 pounds (10 mg), and 17 pounds (15 mg) compared to 2 pounds with placebo In SURPASS-2, Mounjaro lowered patient weight by 17 pounds (5 mg), 21 pounds (10 mg), and 25 pounds (15 mg) compared to 13 pounds with semaglutide

Use cautiously in patients with alcohol-induced liver cirrhosis, due to increased total and acyl carnitine