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Mass Spectrom Rev 26:5178 Dickinson DA, Forman HJ (2002) Glutathione in defense and signaling
One potential reason leptin has not panned out as a therapy on its own is a phenomenon known as leptin resistance. Thats when the body becomes desensitized to the hormone at higher levels, causing a person to feel hungry and eat more even though they have sufficient body fat
However, further research in larger Phase III studies is needed to validate these findings
Enhanced LH secretion and direct interaction with ovarian theca cells may increase ovarian androgen production due to chronic hyperinsulinemia from insulin resistance (Unluhizarci et al., 2021)
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