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"Amylin receptor agonists for obesity treatment: mechanisms and clinical applications." Journal of Clinical Endocrinology & Metabolism , 108(4), 892-904

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In response to physical stimuli, these molecules can initiate signal transduction, modulate the intracellular ion concentration (e.g., calcium, sodium, and chloride), influence cellular tension, volume, and shape, and trigger transcriptional changes, thereby contributing to therapeutic resistance and mediating profound changes in cellular functions, including division, and migration (see sections below)

She adds that some long-term clinical trials have also demonstrated that a high protein diet can help protect against weight gain after weight loss, and with no real adverse effects on bone density or kidney function