P-gp, P-glycoprotein
[ Links ] Looby A, Earleywine M (2007) Negative consequences associated with dependence in daily cannabis users
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If you dont have healthy bile composition or bile flow, you may end up with: Vitamin D and K deficiencies which may affect bone health Vitamin D and A deficiencies which may affect immune health Vitamin E deficiency and lower antioxidants Increased dietary oxalate absorption, which may cause mineral deficiencies such as zinc, magnesium, and iron 14 Deficiencies in these minerals have their own set of consequences Constipation Fatty liver High cholesterol Sleep issues Poor detoxification Symptoms of excess estrogen such as PMS, PCOS, or endometriosis SIBO 3,6 Acid reflux that doesnt improve with antacids is typically bile reflux Increased risk of gallstones Gallbladder Dysfunction Increases SIBO Risk The small intestine is typically not home to many microbes
We also explored several other known regulators of PGC1 activity that are altered in response to 5FU treatment in HCT116, including NRF2, reactive oxygen species and PPAR, but none of these prevented PGC1-driven increases in mitochondrial mass
