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The cytosolic Ca 2+ response was determined as the change in GCaMP6s fluorescence (FGCaMP6s) from baseline to the maximum post-treatment value and the GCaMP6s area under the curve (AUC) was determined using GraphPad Prisim software

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According to the World Health Organization (WHO), in 2022, roughly 1 in 8 people worldwide lived with obesity, with some 890 million adults classified as obese and nearly 2.5 billion adults overweight