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Some of these pathways, such as stress response, metabolism and proteolysis, are known to regulate ageing (Lopez-Otin et al, 2013)

While pancreatitis typically causes severe abdominal pain that radiates to the back, any significant internal inflammation can cause a general sense of body aching or discomfort that an individual might perceive as radiating into the lower extremities

Each component plays a defined role within the overall formulation strategy, contributing to an integrated performance framework rather than isolated effects