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PPIs, antibiotics, NSAIDs, corticosteroids, hormone replacement therapy, hormonal birth control, diuretics, and GLP-1s (indirectly) can deplete folate

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74 Through GLP1R activation and its crosstalk with insulin and IGF1 pathways, incretin mimetics restore mitochondrial integrity, attenuate neuroinflammatory cascades, and preserve synaptic resilience

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After swallowing the tablet, you need to wait at least 30 minutes before eating, drinking anything other than water, or taking other medications