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The most common ones are itchiness and diarrhea

Of course, you can expect some stimulants for this as well in pre-workouts

They are particularly beneficial for vegetarians and vegans (since B12 is found primarily in animal products), older adults with reduced absorption capacity, individuals with digestive conditions such as Crohn's disease or celiac disease, and anyone who has had gastric bypass surgery

Seek immediate emergency care (call 911) for sudden severe shortness of breath, chest pain, rapid heart rate, facial or throat swelling, wheezing, blue discoloration of lips, inability to speak in complete sentences, or confusion

I also prescribe Ozempic (semaglutide) however, this is considered off-label when used specifically for weight loss