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PE-22-28 Safety Considerations# PE-22-28's safety profile is less burdened by mechanism-specific concerns: TREK-1 channels are expressed throughout the body (brain, heart, vasculature, gastrointestinal tract), so systemic TREK-1 blockade could theoretically affect cardiovascular function, pain sensation, and gastrointestinal motility
It can bring down hunger and make it easy to follow restricted-calorie diets
In most healthy people: yes
Healthcare providers should educate patients transitioning from insulin therapy that semaglutide uses an entirely different dosing system
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