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In 2022, the FDA released guidance on the use of NAC as a dietary supplement

J Anal Sci Technol 10, 35.CrossRefGoogle Scholar Hou, Y, Michiels, J, Kerschaver, CV, et al

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The results are inconclusive, but there are some promising results so far: In one small study with just 12 (healthy middle-aged non-smoker) subjects (taking either 500 or 1,000 mg per day liposomal glutathione for four weeks), there was a trend for increasing glutathione levels, although it only became significant in the 500 mg dose after two weeks, which was also the largest increase at 25%

Acknowledgments and Funding The authors would like to thank the University of Iowa Viral Vector Core and Central Microscopy Research Facility for technical assistance