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The microsphere-released drug was effectively taken up by A549 cells and had a strong inhibitory effect on cell migration and invasion by inducing apoptosis and cell cycle arrest in the G2/M phase (Xiong et al., 2021)

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The M3 induced higher gene expression of GPX3 and SOD5 showing a 2-fold and 80-fold increase in mRNA level, respectively

While the short-term safety profile is reasonable with no differences in total adverse side effects, including serious infections, cancers, tuberculosis, or deaths