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FIGURE 5 3.6 FOXO4-DRI promotes apoptosis in senescent cells As established in prior research, FOXO4-DRI competitively binds to p53 with high affinity, thereby disrupting its nuclear interaction with FOXO4

These converge on two outcomes critical to capillary formation: endothelial cell proliferation (driven primarily by ERK1/2 activation) and endothelial cell survival and migration (driven primarily by Akt phosphorylation)

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