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Setmelanotide is currently being studied for treatment of acquired hypothalamic obesity (HO), a condition occurring after injury to the relevant satiety centers, also characterized by hyperphagia and rapid weight gain

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Critically, elevated fasting circulating BCAAs in obesity and insulin resistance primarily indicate impaired peripheral catabolic disposal and altered inter-organ flux, not simply excessive dietary intake

People with a history of B6-related peripheral neuropathy should avoid additional supplementation

However, ensure you increase your intake slowlyadding too much fiber too quickly may worsen gastrointestinal distress