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Description

The PERK-ATF4-CHOP pathway is a central signaling cascade activated in response to ER stress, serving as the cells primary reaction to dysfunction and playing a crucial role in cellular survival

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JAMA 331(5):425-435, 2024

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Effectiveness was assessed on days 1, 2, 4, 7, and 14 after the injury

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This further promotes an autoamplification loop that exaggerates inflammation and cell death and leads to a more severe degree of cell death and a range of inflammation-related responses [95, 96]

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