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Tesamorelin also boosts insulin-like growth factor-1 (IGF-1) levels, which play a vital role in regulating glucose metabolism and fat storage

Transcriptional analysis of colonic epithelial cells: The study performs transcriptional analyses of isolated intestinal epithelial cells from inflamed IL-10-/- mice to identify changes in epithelial differentiation and metabolic profiles using qRT-PCR and assessing mRNA expression of genes involved in epithelial differentiation and various metabolic pathways (mitochondrial metabolism, glycolysis, autophagy)

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Tirzepatide, however, is a dual agonistmeaning it targets both GLP-1 and GIP receptorswhich may lead to stronger effects, both positive and negative