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Several metabolic intermediates, such as long-chain acylcarnitines can cause oxidative stress at high levels and high levels of ROS can then cause damage to cells and tissues, leading to a further decline in performance

Similar content being viewed by others Introduction In 1970, Laugier and Hunziker reported five cases of an unusual acquired macular hyperpigmentation with no underlying disease and two of these patients also displayed longitudinal pigmented streaks on the nails