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Clinical trials show approximately 25 to 39% of weight lost on semaglutide comes from lean body mass, but much of that is liver volume reduction and body water, not skeletal muscle

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When a drug like tirzepatide calms inflammatory signaling throughout the body, the brain benefits too

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In a 24-week semaglutide trial involving men with obesity and type 2 diabetes, participants showed improvements in sperm shape a key measure of sperm quality known as morphology as well as improved cholesterol levels, while testosterone and other hormone levels remained stable