Illegal slimming products may contain sibutramine, a banned serotonergic appetite suppressant that significantly increases this risk
Patients should contact their GP or NHS 111, or in severe cases call 999 or go to A&E, if they experience: Severe, persistent abdominal pain that may radiate to the back (potential sign of pancreatitis ) Signs of gallbladder problems, including pain in the upper right abdomen, fever, or jaundice Rapid heartbeat or palpitations Signs of severe dehydration due to vomiting or diarrhoea, which may lead to acute kidney injury Hypersensitivity reactions including swelling of the face, lips, tongue or throat, breathing difficulties, or severe rash Thoughts of self-harm or suicidal ideation Patients with diabetes taking Saxenda alongside insulin or sulfonylureas may be at increased risk of hypoglycaemia and may need dose adjustments of these medications
3.3 Clinical prevention and management of migraine While migraines are an incurable condition, they can be successfully avoided and managed
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This review included data from the European Medicines Agency (EMA) and Federal Drug Administration (FDA) including product information, the Netherlands Pharmacovigilance Centre and the Teratology Information Service of Switzerland