glp 1 weight loss studies GLP-1 Drugs: Bridging Satiety, Nutrition, and Innovation – Kerry Health And Nutrition Institute Key Facts GPs Should Know

The use of DPP-4is as a comparator provided a highly comparable control group, particularly as both drugs were used in the setting of sole add-on medication to metformin, and both drugs have similar priority in the management of T2D

But there was a problem: the human body breaks down GLP-1 very fast, lasting only minutes in the bloodstream

For people considering long-term GLP-1 use, the safety data is encouraging

2026 Feb;124:106119

Although its a pill, Rybelsus also comes with some challenges: It must be taken daily on an empty stomach, with no eating, drinking or taking other medications for at least 30 minutes, and doctors report that it may not be as effective as injections yet still comes with side effects